hrp0097p2-221 | Adrenals and HPA Axis | ESPE2023

Diabetes insipidus as first manifestation of congenital malformation of the neurocranium

Vasiliu Ioana , Frasinariu Otilia , Mocanu Adriana , Daniel Iancu Ionut , Mihaela Trandafir Laura

Central diabetes insipidus (CDI) at neonatal age may occur in the setting of intracranial abnormalities that affect the hypothalamus-pituitary system. These conditions are characterized by defective production, transport or secretion of antidiuretic hormone (ADH). This results in inappropriately low ADH levels in the setting of increased plasma osmolality. We present the case of an infant born by C-section at 38 weeks of gestation, with bilateral cheilognatopalatoschisis, naso...

hrp0097p2-211 | Diabetes and Insulin | ESPE2023

A rare association between congenital hyperinsulinism and congenital isolated ACTH deficiency

Vasiliu Ioana , Bizim Delia , Frasinariu Otilia , Daniel Iancu Ionut , Mihaela Trandafir Laura

Hyperinsulinemic hypoglycemia (HH) is common in newborns. If hypoglycemia occurs after the first 48 hours following birth, it may be a sign of an underlying condition. We present the case of a baby girl born at 38 weeks of pregnancy, with good adaptation to extrauterine life and blood glucose of 60 mg/dl in the first days of birth. Approximately 2 days after discharge, she was addressed at the emergency unit because of food refusal for approximately 30 hours, with a blood suga...